Mammalian cold receptor afferents: role of an electrogenic sodium pump in sensory transduction.
نویسندگان
چکیده
The responses of specific cold-sensitive afferents and cold-sensitive mechanoreceptors were recorded from rat pudendal nerve. A local infiltration of ouabain into the region of the afferent terminals caused a dramatic increase in discharge at warm temperatures without significant effect on discharge in the cold. These results suggest that an electrogenic sodium pump is the generator potential mechanism imparting cold sensitivity.
منابع مشابه
TRPA1 channels mediate cold temperature sensing in mammalian vagal sensory neurons: pharmacological and genetic evidence.
Cold thermoreceptors have been described in different territories of the vagus nerve. Application of cold temperature to these visceral afferents can evoke major protective reflexes and thermoregulatory responses. However, virtually nothing is known about the transduction mechanisms underlying cold sensitivity in vagal afferents. Here, we investigated the effects of cold stimulation on intracel...
متن کاملAn electrogenic sodium pump and baroreceptor function in normotensive and spontaneously hypertensive rats.
Postexcitatory depression (PED) and adaptation were examined in slowly adapting aortic baroreceptors of normotensive rats (NTR) and spontaneously hypertensive rats (SHR); an aortic arch-aortic nerve preparation in vitro was used. PED was elicited either mechanically by employing single or double pressure steps, or electrically by antidromic stimulation of the aortic nerve. During PED the axon o...
متن کاملSensory transduction and electrical signaling in guard cells.
Guard cells are a valuable model system for the study of photoreception, ion transport, and osmoregulation in plant cells. Changes in stomatal apertures occur when sensing mechanisms within the guard cells transduce environmental stimull into the ion fluxes and biosynthesis of organic solutes that regulate turgor. The electrical events mediating sensory transduction in guard cells can be charac...
متن کاملThe ADP receptor P2Y1 is necessary for normal thermal sensitivity in cutaneous polymodal nociceptors
BACKGROUND P2Y1 is a member of the P2Y family of G protein-coupled nucleotide receptors expressed in peripheral sensory neurons. Using ratiometric calcium imaging of isolated dorsal root ganglion neurons, we found that the majority of neurons responding to adenosine diphosphate, the preferred endogenous ligand, bound the lectin IB4 and expressed the ATP-gated ion channel P2X3. These neurons rep...
متن کاملIs the Second Sodium Pump Electrogenic?
Transepithelial sodium transport is a process that involves active Na(+) transport at the basolateral membrane of the epithelial cell. This process is mediated by the Na(+)/K(+) pump, which exchanges 3 internal Na(+) by 2 external K(+) inducing a net charge movement and the second Na(+) pump, which transports Na(+) accompanied by Cl(-) and water. It has been suggested that this pump could also ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید
ثبت ناماگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید
ورودعنوان ژورنال:
- Brain research
دوره 73 1 شماره
صفحات -
تاریخ انتشار 1974